main relay gives u ignition switched power to the efi system & power for the fuel pump,so yes, no main relay= def no start
thats the only things that come of the engine harness that need wiring,gauges(not fuel gauge,u just have to wire that to new sender in tank,if new tank used),reverse lights,fan control.
if u go EG+ harness,battery on opposite side,redirect alternator feed.
words make it sound daunting,it will make a whole lot more sense once u see it all laid out in front of u.

