the f22b and f20b are essentially the same block with different bore/strokes to achive the difference in displacement. The f22a is also of the same family of castings, so physically its going to be very easy to drop right in. The f22b is going to be easier as it is a SOHC vtec head and therefore ancillierie mounts for ps/ac etc will be more likely to fit.

The wiring loom will be easy, i havent looked at it, but from the countless swaps i have done, the most likely pinouts will be for vtec, vtec pressure, maybe some resistors for the injectors, and iab, o2. But nothing with half a brain wont make happen.